Randomised controlled trial of long term efficacy of captopril on preservation of kidney function in normotensive patients with insulin dependent diabetes and microalbuminuria.

immunosuppression, other factors including EpsteinBarr virus infection, chronic antigen stimulation, and proto-oncogenes, have been implicated in the pathogenesis of the different clinical and histopathological manifestations of AIDS related non-Hodgkin’s lymphoma, whereas human herpes virus type 8 may be an infectious cofactor which is required for all forms of Kaposi’s sarcoma. Our data indicate that patients cease to be at risk of Kaposi’s sarcoma once immune function has been improved by combination therapy. Conversely, patients with a history of severe immunodeficiency continue to be at risk of non-Hodgkin’s lymphoma, despite antiretroviral combination therapy. Although the initiation of carcinogenesis requires an immunodeficient state, the factors promoting the development of non-Hodgkin’s lymphoma further along the causal chain do not seem to be related to immune function or are related to aspects not affected by antiretroviral combination therapy. Because of the large number of susceptible patients with a history of severe immunodeficiency, the fall in the incidence of non-Hodgkin’s lymphoma will probably lag behind that observed for other opportunistic diseases. Non-Hodgkin’s lymphoma will thus remain a relatively common complication among patients treated with antiretroviral combination therapy.